Does disrupting the orbitofrontal cortex alter sensitivity to punishment? A potential mechanism of compulsivity.

Abnormal orbitofrontal cortex (OFC) activity is one of the most common findings from neuroimaging studies individuals with compulsive disorders such as substance use disorder and obsessive-compulsive disorder. The nature this abnormality complex, however, some reporting OFC to be over-active in relative controls, whereas other report it being under-active, a further set both directions within same individuals. has been implicated broad range cognitive processes decision-making goal-directed action. dysfunction could thus impair action, leading kinds cognitive/behavioral deficits observed disorders. One deficit that arise result an altered sensitivity punishment, which core characteristics displayed by across multiple types It is, therefore, aim current review assess evidence implicating adaptation punishment attempt identify critical factors determine relationship. We distill analysis guidelines for future attempting precise role punishment. (PsycInfo Database Record (c) 2021 APA, all rights reserved).